Protein name:
Mothers against decapentaplegic homolog 1 (MAD homolog 1;Mothers against DPP homolog 1) ;
Alternative:
SMAD family member 1 (SMAD 1;Smad1) ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Interacts with HGS, NANOG and ZCCHC12 (By similarity). May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit, CREB-binding protein (CBP), p300, SMURF1, SMURF2 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with SKOR1. Interacts (via MH2 domain) with LEMD3. Binding to LEMD3 results in at least a partial reduction of receptor-mediated phosphorylation.
Function:
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD).
Subcellular Location:
Cytoplasm
Nucleus
Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane (By similarity). Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome.
Protein Attributes:
50:
MNVTSLFSFT | SPAVKRLLGW | KQGDEEEKWA | EKAVDALVKK | LKKKKGAMEE |
100:
LEKALSCPGQ | PSNCVTIPRS | LDGRLQVSHR | KGLPHVIYCR | VWRWPDLQSH |
150:
HELKPLECCE | FPFGSKQKEV | CINPYHYKRV | ESPVLPPVLV | PRHSEYNPQH |
200:
SLLAQFRNLG | QNEPHMPLNA | TFPDSFQQPN | SHPFPHSPNS | SYPNSPGSSS |
250:
STYPHSPTSS | DPGSPFQMPA | DTPPPAYLPP | EDPMTQDGSQ | PMDTNMMAPS |
300:
LPSEINRGDV | QAVAYEEPKH | WCSIVYYELN | NRVGEAFHAS | STSVLVDGFT |
350:
DPSNNKNRFC | LGLLSNVNRN | STIENTRRHI | GKGVHLYYVG | GEVYAECLSD |
400:
SSIFVQSRNC | NYHHGFHPTT | VCKIPSGCSL | KIFNNQEFAQ | LLAQSVNHGF |
450:
ETVYELTKMC | TIRMSFVKGW | GAEYHRQDVT | STPCWIEIHL | HGPLQWLDKV |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Mouse
Rat
ELISA Kit for Bovine MAD homolog 1
ELISA Kit for Bovine MAD homolog 1
ELISA Kit for Bovine MAD homolog 1
ELISA Kit for Bovine MAD homolog 1
CLIA Kit for Bovine MAD homolog 1
CLIA Kit for Bovine MAD homolog 1
CLIA Kit for Bovine MAD homolog 1
CLIA Kit for Bovine MAD homolog 1
Polyclonal Antibody for Bovine MAD homolog 1
Polyclonal Antibody for Bovine MAD homolog 1
Polyclonal Antibody for Bovine MAD homolog 1
Polyclonal Antibody for Bovine MAD homolog 1
Monoclonal Antibody for Bovine MAD homolog 1
Monoclonal Antibody for Bovine MAD homolog 1
Monoclonal Antibody for Bovine MAD homolog 1
Monoclonal Antibody for Bovine MAD homolog 1
Protein for Bovine MAD homolog 1
Protein for Bovine MAD homolog 1
Protein for Bovine MAD homolog 1
Protein for Bovine MAD homolog 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Cloning and bioinformatic analysis of cDNA encoding cattle Smad1 gene."
Zhang X.
,
Xu S.
Submitted (2006-08) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Hereford .
tissue :
Ascending colon .